Why does RNAi need to be inserted as a double strand?

Posted by admin on Mar 6, 2008 in Chatter | 2 comments



It would seem that only the antisense strand would be necessary to match the antisense RNAi to the sense mRNA and identify it for cleavage. Is the double strand necessary for the RNAi to be recognized and/or bound to the Dicer and/or RISC proteins?

rnai
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